Protects against the main causes of cervical cancer, from which about 179,000 women died in 2020 in lower-income countries.
Protects against the main causes of cervical cancer, from which about 179,000 women died in 2020 in lower-income countries.
Latest articles about HPV Routine vaccines: HPV
HPV vaccine coverage increased from 7% in 2019 to 10% in 2022. This was largely driven by countries introducing the vaccine into their national immunisation programmes. By the end of 2022, 32 countries had successfully launched their HPV vaccine national programme with Gavi support, fully immunising more than 16.3 million girls since 2014, which translates to over 387,000 cervical cancer deaths averted with Gavi support.
In April 2022, the Strategic Advisory Group of Experts on Immunization (SAGE) recommended a one- or two-dose schedule for HPV vaccine; subsequently, the WHO position paper was released in December 2022. In response to this potential gamechanger for Gavi’s HPV vaccine programme – and to overcome the challenges and impact of the COVID-19 pandemic on HPV vaccine delivery – in December 2022, the Gavi Board approved the revitalisation of Gavi’s HPV vaccine programme. This revitalisation initiative committed to reach 86 million adolescent girls with HPV vaccine by 2025 through: (1) accelerating quality introductions; (2) rapidly improving global and national coverage; and (3) generating long- term programmatic sustainability.
With efforts underway to strengthen programme delivery and facilitate more introductions, and long-standing supply challenges easing thanks to increased vaccine production and the new one-dose recommendation, coverage is expected to further increase in the coming years.
Cervical cancer caused 179,000 deaths in 2020 in lower- income countries. However, human papillomavirus (HPV) is associated with over 90% of these cancers, and vaccination provides high protection against cervical cancer. The HPV vaccine has amongst the highest impact of all Gavi-supported vaccines, with 17.4 deaths averted per 1,000 children vaccinated, and is the key intervention towards achieving the global strategy for cervical cancer elimination.
HPV vaccination is critical to reducing cervical cancer, especially in lower-income countries with a high disease burden and less developed cervical cancer screening and treatment programmes. It is also a bridge to improving women’s and girls’ health through increased touchpoints with health services, and therefore an opportunity to positively impact gender equity.
Historically, the high cost of HPV vaccine, limited supply and challenges of reaching adolescent girls to deliver immunisation have been barriers to introduction in lower-income countries. Gavi is working to bridge the equity gap by providing support for HPV vaccine and ensuring sustainable prices. Gavi supports HPV vaccines for national introduction, with immunisation of multi-age cohorts of girls aged 9–14 years.
These objectives have been facilitated by an easing of global HPV vaccine supply constraints, the permissive recommendation by SAGE for a one-dose schedule (compared with the two-dose schedule) and the waning of COVID-19 pandemic-related delivery disruptions. Nonetheless, by end 2022, over 16 million girls had been reached with HPV vaccine with Gavi support.
In December 2022 the Gavi Board approved the revitalisation of the Alliance’s HPV vaccine programme with a US$ 600+ million investment through 2025. With the additional funding in place, the Alliance has set an ambitious goal to reach over 86 million girls with HPV vaccine by 2025, aiming to avert over 1.4 million future deaths from cervical cancer.
The revitalisation will allow Gavi to dedicate additional funding to help countries and partners reach more girls than ever with this life-saving vaccine – through expanded funding for vaccines, introduction and campaign costs;, and expanded support for technical assistance.
Gavi-eligible countries can also utilise health system strengthening (HSS) funding to develop tailored approaches to improve and sustain HPV vaccination coverage.
Gavi procures three HPV vaccines that have been prequalified by WHO. Through long-term agreements with manufacturers, supply is likely to be sufficient to meet the ongoing demand for delayed MAC catch-up campaigns and routine introductions, supported by the adoption of a one-dose schedule by countries, and suppliers ramping up production.
A creative solution to a persistent problem: the power of media to drive uptake of vaccines
A new partnership between Gavi and Girl Effect is using the power of mass media to bust myths and help reverse the decline in vaccine coverage across Africa
Against the clock: Kenyan runner, 15, organises 10km run to beat cervical cancer
More than 3,200 Kenyan women die of vaccine-preventable cervical cancer each year, but teenage athlete Stecy Bosse of Kisumu is racing to change that.
Cervical cancer can be beaten - the key is vaccinating young girls
Cervical cancer is one of the most common cancers in women. Mortality rates in sub-Saharan Africa are three times higher than the global average.
HPV-linked cancers – which are vaccine preventable in most cases – are a particular threat to trans people, a review study recently found.
Beyond cervical cancer: How Bhutan is winning the war against HPV
The small Himalayan country of Bhutan plans to eliminate cervical cancer, and sees vaccinating boys as well as girls as being crucial to that goal.
Eritrea touts screening and HPV vaccines to drive down cervical cancer rates
The second commonest cancer among women aged 15 to 44, and often diagnosed late, cervical cancer has a brutal mortality rate in Eritrea. Now, community health workers are pushing prevention.
Professor Nayi Zongo is the President of the Burkinabe Coalition Against Cancer (COBUCAN). We discuss the importance of vaccination against human papillomavirus to prevent cervical cancer, which claims the lives of hundreds of women each year in…
Zambian broadcaster Karen Nakawala was diagnosed with cervical cancer four years ago. She survived, though many friends she made didn’t. Today she’s on a mission to convince girls across the world to get the HPV vaccine.
Why southern and eastern Africa have the world’s highest rates of cervical cancer
Southern and East African countries have some of the highest rates1 of cervical cancer in the world. Prof Lynette Denny explains why, and what is being done to improve women’s health.
Shame, myths and needlephobia leave Ugandan women at high risk of preventable cancer
Cervical cancer is vaccine-preventable in 95% of cases. It also remains Uganda’s single most common cancer, affecting three times as many women and girls there than on global average. VaccinesWork finds out why.
Q&A: Rolling out HPV vaccine in Burkina Faso
Dr Samiratou Ouédraogo is a lecturer at Joseph Ki-Zerbo University in Burkina Faso, deputy coordinator of the ReAAC (Research and Action Against Cancer) Chair, and also co-founder of Women in Global Health in French-speaking West Africa. She…
“We lose so many women every day”: cervical cancer in low-resource settings
In rural areas of South Africa, women with cervical cancer are often diagnosed late, and hospitals don’t necessarily have the resources to care for them, says Dr Nwabisa Giyose.
Eligible countries can access detailed guidelines to manage the support they receive from Gavi.
