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When is a vaccine not a vaccine?

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3 December 2020 – Explainer

Most vaccines are given to healthy people to prevent infection with a disease-causing organism, but sometimes vaccines are used to fight an existing infection or illness. Such ‘therapeutic’ vaccines are being developed for numerous illnesses, including dengue, cholera and cancer.

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The world needs Gavi now more than ever

By Jose Manuel Barroso, Chair-Elect, Gavi

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3 September 2020 – Article

By Dr Seth Berkley, CEO of Gavi, the Vaccine Alliance

The Gavi COVAX AMC Explained

13 October 2020

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Janet, mother of twins, tells fellow mothers.

Most vaccines are given to healthy people to prevent infection with a disease-causing organism, but sometimes vaccines are used to fight an existing infection or illness. Such ‘therapeutic’ vaccines are being developed for numerous illnesses,…

Scientists around the world are working faster than ever to find vaccines that could stop the spread of COVID-19. Now, nearly a year on from the start of the pandemic, we have several promising vaccines on the brink of going through regulatory…

The COVID-19 vaccine race

Pre-clinical
154vaccines
are being explored in lab experiments and animals
PHASE 1
21 vaccines
are undergoing safety tests in healthy young individuals
Phase 2
13vaccines
are being tested in broader groups of people
Phase 3
10vaccines
are in large international trials to test their impact on COVID-19
APPROVED
0vaccines
are approved and licensed for general use

Scientists around the world are working at an unprecedented pace to test different types of vaccines that could help to stop the spread of COVID-19. (Last updated: 22 October 2020)

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Janet, mother of twins, tells fellow mothers.

The COVID-19 pandemic now threatens global progress on preventing and treating childhood pneumonia, potentially reversing decades of health gains for the world’s most vulnerable children.

The Ghanaian Ministry of Health and the Ghana Health Service, with support from UNICEF, WHO, Gavi and partners, undertook a preventive mass yellow fever vaccination campaign from 12–18 November.

This week Gavi signed a historic agreement with the International Organization for Migration (IOM) to improve immunisation coverage for migrants and forcibly displaced persons around the world. IOM’s South Sudan Communications Officer, Liatile…

Throughout the country, all year-round, routine and supplementary immunisation activities took place to ensure that no child was left behind from being vaccinated.

 

COVID-19

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Janet, mother of twins, tells fellow mothers.

Scientists around the world are working faster than ever to find vaccines that could stop the spread of COVID-19. Now, nearly a year on from the start of the pandemic, we have several promising vaccines on the brink of going through regulatory…

As companies race to develop COVID-19 vaccines, some development processes have been run in parallel to stop the pandemic as quickly as possible. Yet safety remains paramount; now that we are on the brink of rolling out some of the vaccines that…

Scientists have been racing to develop COVID-19 vaccines that could reach millions, yet many of the studies have surprisingly small sample sizes drawn from the clinical trials. Does that matter?

Fluvoxamine has shown positive results in early trials.

 

COVAX

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Scientists around the world are working faster than ever to find vaccines that could stop the spread of COVID-19. Now, nearly a year on from the start of the pandemic, we have several promising vaccines on the brink of going through regulatory…

As companies race to develop COVID-19 vaccines, some development processes have been run in parallel to stop the pandemic as quickly as possible. Yet safety remains paramount; now that we are on the brink of rolling out some of the vaccines that…

Despite the benefit of all the recommended public health measures in preventing transmission, vaccines still provide us with the best chance of our lives returning to some semblance of normality.

CEPI spoke with vaccine safety expert, Dr Robert Chen, Science Director of The Brighton Collaboration – the largest global organisation of scientific experts on vaccine safety – about how vaccine safety is assessed in clinical trials and how…

Interim analysis of the AstraZeneca/Oxford COVID-19 vaccine candidate – to which Gavi has secured access – suggests an efficacy of 62– 90%. Crucially, the vaccine can be administered and distributed using existing health care and supply chain…

 

Country stories

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Janet, mother of twins, tells fellow mothers.

The Ghanaian Ministry of Health and the Ghana Health Service, with support from UNICEF, WHO, Gavi and partners, undertook a preventive mass yellow fever vaccination campaign from 12–18 November.

Despite the benefit of all the recommended public health measures in preventing transmission, vaccines still provide us with the best chance of our lives returning to some semblance of normality.

When children fall ill with diarrheal disease, hospital bills and indirect costs often add up to have a significant impact on families, communities, and economies.

COVID-19 vaccines are set to become the quickest vaccines in history to go from initial trials to rollout, but what lessons can we learn from its speedy predecessor: the Ebola vaccine?

 

International

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September 2020 marks the 75th anniversary of the United Nations General Assembly (UNGA). This year, the focus of the high-level General Debate is the importance of effective multilateralism.

Since 2000, Gavi has been increasing equitable access to vaccines by working with the world’s poorest countries. Yet during a pandemic, more prosperous countries are also at risk of falling through the net. How will Gavi respond?

As the devastating consequences of the pandemic unfold across the world, COVID-19 is making long-lasting changes in global health

On 4 June, global leaders met at a virtual event to pledge support for Gavi, the Vaccine Alliance, and in the process made history by reaching new global health milestones

The pandemic will only strengthen our commitment to vaccinate vulnerable communities. On 4 June 2020 Gavi will hold its third donor pledging conference online with the aim to raise vital funds for the next five years.

Last updated: 2 Dec 2020

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