The Vaccine Innovation Prioritisation Strategy (VIPS) represents an unprecedented three-year collaboration between the Gavi Secretariat, World Health Organization (WHO), Bill & Melinda Gates Foundation (BMGF), United Nations Children’s Fund (UNICEF) and PATH– known as the VIPS Alliance - to develop a single integrated framework to evaluate and prioritise vaccine product innovations and to drive these innovations forward.
VIPS logo

 

An Alliance initiative

Gavi logo

 

WHO logo

 

BMGF

 

Path

 

UNICEF logo

 

Innovative approaches are needed to help to address immunisation barriers and achieve immunisation coverage and equity goals. Vaccine product innovations offer important means to simplify logistics, increase the acceptability and safety of immunisation, minimise missed opportunities, and facilitate outreach. There is increasing recognition of the need to employ targeted solutions to extend vaccine access to reach the unreached.

The VIPS process involved in-depth research, stakeholder consultations, and development and application of a methodology capable of evaluating a variety of technologies at different stages along the product development pipeline continuum. The work required understanding countries’ needs to consider the expected financial and non-financial impacts of innovations; developing common principles across the Alliance to assess the long-term benefits of product innovations; and convening a platform of stakeholders to articulate a clear and aligned perspective on priority innovations.

By prioritising innovations in vaccine products, the goal of VIPS is to provide greater clarity to manufacturers and partners to inform and influence investment decisions. VIPS outcomes also represent a first step to mobilise key decision-makers and funders and chart a strategic pathway forward for the prioritised innovations.

More details can be found on the methodology, process and outcomes; scope of innovations assessed within VIPS; and VIPS Steering Committee here:

Final VIPS prioritisation

The VIPS – Vaccine Innovation Prioritisation Strategy – process concluded in May 2020 with a decision to prioritise 3 innovations / approaches for which the Alliance will engage in to advance development, policy and access:

  • Upstream novel delivery device – Microarray patches,
  • A combined formulation, regulatory, and novel programmatic approach to vaccine management – Heat stable and Controlled Temperature Chain qualified vaccines, and 
  • An implementation/system innovation – Barcodes on primary packaging

The next steps for the VIPS Alliance are to define end-to-end strategies for the three prioritised innovations, including developing clear action plans to accelerate their advancement to uptake and impact.

Assessment documents

Phase I – Initial Prioritisation of 24 Innovations

Autodisable Sharps Injury Protection Syringes

1 VIPS Phase I Executive Summary Autodisable Sharps Injury Protection Syringes pdf

VIPS Phase I executive summary:
Autodisable sharps - injury protection
syringes
June 2019
Autodisable (AD) sharps -injury protection (SIP)
syringes
About AD SIP syringes
? AD SIP syringes are single -use,…

1 VIPS Phase I Technical Note Autodisable Sharps Injury Protection Syringes pdf


12.06.2019 Page 1 of 18
VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
A utodisable (A D ) sharps -injury protection (SIP)

Barcodes on Primary Containers

2 VIPS Phase I Executive Summary Barcodes on Primary Containers pdf

VIPS Phase I executive summary:
Barcodes
June 2019
Barcodes
About Barcodes
? Barcodes are symbols that encode information such as product numbers, serial numbers,
supplier data, batch numbers and expiry dates…

2 VIPS Phase I Technical Note Barcodes on Primary Containers pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Barcodes
Comparator: Use without innovation (i.e. no…

Blow Fill Seal Primary Containers

3 VIPS Phase I Executive Summary Blow Fill Seal Primary Containers pdf

VIPS Phase I executive summary:
Blow - fill - seal primary containers
June 2019
Blow -fill -seal (BFS) primary containers
About BFS primary containers
? BFS is a single, continuous, aseptic filling process in which a…

3 VIPS Phase I Technical Note Blow Fill Seal Primary Containers pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
B low -fill -seal primary container s
Comparator ?:…

Bundling Devices

4 VIPS Phase I Executive Summary Bundling Devices pdf

VIPS Phase I executive summary:
Bundling devices
June 2019
Bundling devices
About bundling devices
? Bundling devices allow vaccine components to be physically connected
or placed together in the same secondary…

4 VIPS Phase I Technical Note Bundling Devices pdf



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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Bundling devices
Use without innovation (i.e. vaccine…

Combined Vaccine Vial Monitor VVM and Threshold Indicators TI

5 VIPS Phase I Executive Summary Combined Vaccine Vial Monitor VVM and Threshold Indicators TI pdf

VIPS Phase I executive summary:
Combined Vaccine Vial Monitor (VVM) and
Threshold Indicators (TI)
June 2019
Combined Vaccine Vial Monitor (VVM) and
Threshold Indicators (TI)
About Combined VVM and TIs
?…

5 VIPS Phase I Technical Note Combined Vaccine Vial Monitor VVM and Threshold Indicators TI pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Combined Vaccine Vial M onitor (VVM) and Threshold

Compact Prefilled Auto-disable Devices

6 VIPS Phase I Executive Summary Compact Prefilled Auto disable Devices pdf

VIPS Phase I executive summary:
Compact prefilled auto - disable devices
June 2019
Compact prefilled auto -disable devices (CPADs)
About CPADs
? CPADs are integrated primary containers and injection devices prefilled…

6 VIPS Phase I Technical Note Compact Prefilled Auto disable Devices pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Compact prefilled auto -disable device s (CPAD s )

Disposable Syringe Jet Injectors

7 VIPS Phase I Executive Summary Disposable Syringe Jet Injectors pdf

VIPS Phase I executive summary:
Disposable - syringe jet injectors (DSJIs)
June 2019
Disposable -syringe jet injectors (DSJIs)
About DSJIs
? DSJIs are devices that deliver vaccines in a narrow, high -pressure liquid…

7 VIPS Phase I Technical Note Disposable Syringe Jet Injectors pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Disposable -syringe jet injector s (DSJI s )
Comparator…

Dry Heat Stable Formulations

8 VIPS Phase I Executive summary Dry Heat Stable Formulations pdf

VIPS Phase I executive summary:
Heat - stable/Controlled Temperature Chain
(CTC) qualified dry formulations
June 2019
Heat -stable/controlled temperature chain (CTC)
qualified dry formulations
About Heat -stable/…

8 VIPS Phase I Technical Note Dry Heat Stable Formulations pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF

Heat -stable/ controlled temperature chain ( CTC )

Dual Chamber Delivery Devices

9 VIPS Phase I Executive summary Dual Chamber Delivery Devices pdf

VIPS Phase I executive summary:
Dual - chamber delivery devices
June 2019
Dual -chamber delivery devices
About Dual -chamber delivery devices
? Dual chamber delivery devices are fully integrated
reconstitution…

9 VIPS Phase I Technical Note Dual Chamber Delivery Devices pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Dual -chamber delivery d evice s
Comparator ? : Single…

Dual Chamber Vials

10 VIPS Phase I Executive Summary Dual Chamber Vials pdf

VIPS Phase I executive summary:
Dual chamber vials
June 2019
Dual chamber vials
About dual chamber vials
? Dual -chamber vials are integrated primary containers with a
reconstitution feature.
? They contain…

10 VIPS Phase I Technical Note Dual Chamber Vials pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Dual chamber v ial s
Comparator ? : Single dose vial…

Freeze Damage Resistant Liquid Formulations

11 VIPS Phase I Executive Summary Freeze Damage Resistant Liquid Formulations pdf

VIPS Phase I executive summary:
Freeze damage resistant liquid formulations
June 2019
Freeze damage resistant liquid formulations
About Freeze damage resistant liquid formulations
? Many vaccines are freeze -sensitive ,…

11 VIPS Phase I Technical Note Freeze Damage Resistant formulations pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Freeze damage resistant liquid formulations
Comparator : Use without…

Freeze Indicator on Primary Vaccine Containers

12 VIPS Phase I Executive Summary Freeze Indicator on Primary Vaccine Containers pdf

VIPS Phase I executive summary:
Freeze indicator on primary vaccine
containers
June 2019
Freeze indicator on primary vaccine containers
About Freeze indicator on primary vaccine containers
? Freeze indicators are…

12 VIPS Phase I Technical Note Freeze Indicator on Primary Containers pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Freeze Indicator on primary vaccine container s

Intradermal Devices

13 VIPS Phase I Executive Summary Intradermal Devices pdf

VIPS Phase I executive summary:
Intradermal (ID) Devices
June 2019
Intradermal (ID) Devices
About ID Devices
? ID devices and delivery devices used to inject vaccines into epidermal and dermal layers of the
skin .…

13 VIPS Phase I Technical Note Intradermal Syringes pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Intradermal (ID) syringes
(not in cluding prefilled ID…

Liquid Heat Stable Formulations

14 VIPS Phase I Executive summary Liquid Heat Stable Formulations pdf

VIPS Phase I executive summary:
Heat - stable/Controlled Temperature Chain
(CTC) qualified liquid formulations
June 2019
Heat -stable/controlled temperature chain (CTC)
qualified liquid formulations
About Heat -…

14 VIPS Phase I Technical Note Liquid Heat Stable Formulations pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Heat -stabl e /c ontrolled temperature chain (C TC )

Microarray Patches

15 VIPS Phase I Executive Summary Microarray Patches pdf

VIPS Phase I executive summary:
Microarray patches (MAPs)
June 2019
Microarray patches (MAPs)
About MAPs
? MAPs consists of an array of micro -projections on a patch .
? These micro -projections are coated with or…

15 VIPS Phase I Technical Note Microarray Patches pdf


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VIPS is a Vaccine Alliance project fro m Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Microarray patch es (MAP)
Comparator s? : Single dose…

Oral Fast Dissolving Tablets

16 VIPS Phase I Executive summary Oral Fast Dissolving Tablets pdf

VIPS Phase I executive summary:
Oral fast dissolving tablets
June 2019
Oral fast dissolving tablets
About Oral fast dissolving tablets (FDTs)
? Fast dissolving tablets are freeze dried vaccine tablets that disintegrate…

16 VIPS Phase I Technical Note Oral Fast Dissolving Tablets pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Oral fast dissolving tablet s
Comparator s? :…

Plastic Needles For Reconstitution

17 VIPS Phase I Executive Summary Plastic Needles For Reconstitution pdf

VIPS Phase I executive summary:
Plastic needles (for reconstitution)
June 2019
Plastic needles (for reconstitution)
About Plastic needles (for reconstitution)
? Polymer needles designed to be capable of penetrating vial…

17 VIPS Phase I Technical Note Plastic Needles for Reconstitution pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
P lastic needl e s (for recon stitution )
Comparator :…

Prefilled Blow Fill Seal Droppers Dispensers

18 VIPS Phase I Executive Summary Prefilled Blow Fill Seal Droppers Dispensers pdf

VIPS Phase I executive summary:
Prefilled polymer blow - fill - seal droppers /
dispensers
June 2019
Prefilled polymer blow -fill -seal (BFS) droppers /
dispensers
About prefilled polymer BFS droppers/dispensers…

18_VIPS Phase I_Technical Note Prefilled Blow Fill Seal Droppers Dispensers pdf


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VIPS is a Vaccine Alliance project from Ga vi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Prefilled polymer BFS dropper s /dispenser s
Comparator ?: Single dose…

Prefilled Dry Powder Intranasal Devices

19 VIPS Phase I Executive Summary Prefilled Dry Powder Intranasal Devices pdf

VIPS Phase I executive summary:
Prefilled dry - powder intranasal (DPIN)
devices
June 2019
Prefilled dry -powder intranasal (DPIN) devices
About Prefilled dry -powder intranasal (DPIN) devices
? A wide range of…

19 VIPS Phase I Technical Note Prefilled Dry Powder Intranasal Devices pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Prefilled dry -powder intranasal (DPIN ) device s

Radio Frequency Identification RFID

20 VIPS Phase I Executive summary Radio Frequency Identification RFID pdf

VIPS Phase I executive summary:
Radio Frequency Identification (RFID)
June 2019
Radio Frequency Identification (RFID)
About Radio Frequency Identification (RFID)
? RFID tags can be affixed to vaccine primary containers and…

20 VIPS Phase I Technical Note Radio Frequency Identification RFID pdf


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VIPS is a Vaccine Alliance project fro m Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF

Radio Frequency Identification (RFID)
Comparator:…

Reconstitution Vial Adapters

21 VIPS Phase I Executive Summary Reconstitution Vial Adapters pdf

VIPS Phase I executive summary:
Reconstitution vial adapters
June 2019
Reconstitution vial adapters
About Reconstitution vial adapters
? Vial adapters can facilitate either:
? Vial to vial reconstitution using a reuse…

21 VIPS Phase I Technical Note Reconstitution Vial Adapters pdf


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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF

Reconstitution vial adapters
Comparator ? : Use…

Single Chamber Cartridge Injectors

22 VIPS Phase I Executive Summary Single Chamber Cartridge Injectors pdf

VIPS Phase I executive summary:
Single - chamber cartridge injectors
June 2019
Single -chamber cartridge injectors
About single -chamber cartridge injectors
? Vaccine delivery device that has a needle and that requires…

22 VIPS Phase I Technical Note Single Chamber Cartridge Injectors pdf


11.06.2019 Page 1 of 18
VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Single -chamber cartridge injectors
Comparator : Single…

Solid Dose Implants

23 VIPS Phase I Executive Summary Solid Dose Implants pdf

VIPS Phase I executive summary:
Solid - dose implants with applicator
June 2019
Solid -dose implants (SDIs) with applicator
About SDIs
? SDIs consist of vaccines (including antigens, adjuvants and excipients) that have…

23 VIPS Phase I Technical Note Solid Dose Implants pdf


11.06.2019 Page 1 of 22
VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Solid -dose implants (with applicator) a

Comparator…

Sublingual Dosage Forms

24 VIPS Phase I Executive Summary Sublingual Dosage Forms pdf

VIPS Phase I executive summary:
Sublingual dosage forms
June 2019
Sublingual dosage forms
About Sublingual dosage forms
? Sublingual dosage forms are tablets and thin films that are placed under the tongue and

24 VIPS Phase I Technical Note Sublingual Dosage Forms pdf


11.06.2019 Page 1 of 30
VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill & Melinda Gates Foundation, PATH and UNICEF
Sublingual dosage form s
Comparator s?:
?…

Phase II – Final Prioritisation of 9 Innovations

Autodisable Sharps Injury Protection AD SIPs

1 VIPS Phase II Executive Summary Autodisable Sharps Injury Protection AD SIPs pdf

1
VIPS Phase II executive summary:
Autodisable Sharps - Injury Protection
Syringes (AD SIPs)
March 2020
2
Autodisable (AD) sharps -injury protection (SIP)
syringes
About AD SIP syringes
? AD SIP…

1 VIPS Phase II Technical Note Autodisable Sharps Injury Protection Syringes pdf



VIPS PHASE 2 TECHNICAL NOTE

Autodisable sharps injury protection syringes




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Barcodes on Primary Containers

2 VIPS Phase II Executive Summary Barcodes on Primary Containers pdf

1
VIPS Phase II executive summary:
Barcodes on primary containers
March 2020
2
Barcodes on primary containers
About Barcodes
? Barcodes are symbols that encode information such as product numbers, serial…

2 VIPS Phase II Technical Note Barcodes on Primary Containers pdf



VIPS PHASE 2 TECHNICAL NOTE

Barcodes




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Combined Vaccine Vial Monitor VVM and Threshold Indicators TI

3 VIPS Phase II Executive Summary Combined Vaccine Vial Monitor VVM and Threshold Indicators TI pdf

1
VIPS Phase II executive summary:
Combined Vaccine Vial Monitor (VVM)
and Threshold Indicator (TI)
March 2020
2
Combined Vaccine Vial Monitor (VVM) and Threshold
Indicator (TI)
Temptime
Reading of…

3 VIPS Phase II Technical Note Combined Vaccine Vial Monitor VVM and Threshold Indicators TI pdf



VIPS PHASE 2 TECHNICAL NOTE

Combined Vaccine Vial Monitor and Threshold Indicator




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Compact Prefilled Autodisable Devices

4 VIPS Phase II Executive Summary Compact Prefilled Autodisable Devices pdf

1
VIPS Phase II executive summary:
Compact prefilled auto - disable devices
(CPADs)
March 2020
2
Compact prefilled auto -disable devices (CPADs)
About CPADs
? CPADs are integrated primary containers and…

4 VIPS Phase II Technical Note Compact Prefilled Auto disable Devices pdf



VIPS PHASE 2 TECHNICAL NOTE

Compact prefilled auto -disable device (CPAD)




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Dual Chamber Delivery Devices

5 VIPS Phase II Executive Summary Dual Chamber Delivery Devices pdf

1
VIPS Phase II executive summary:
Dual - chamber delivery devices
March 2020
2
Dual -chamber delivery devices
About dual -chamber delivery devices
? Dual chamber delivery devices are prefilled with liquid…

5 VIPS Phase II Technical Note Dual Chamber Delivery Devices pdf



VIPS PHASE 2 TECHNICAL NOTE

Dual -chamber delivery device




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VIPS is a Vaccine Alliance project from Gavi, World Health Organization, Bill…

Freeze Damage Resistant Formulations

6 VIPS Phase II Executive Summary Freeze Damage Resistant Formulations pdf

1
VIPS Phase II executive summary:
Freeze damage resistant liquid
formulations
March 2020
2
Freeze damage resistant (FDR) liquid formulations
Stage of development
? Excipients that could be used to improve…

6 VIPS Phase II Technical Note Freeze Damage Resistant Formulations pdf



VIPS PHASE 2 TECHNICAL NOTE

Freeze Damage Resistant Liquid Formulations




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Heat Stable CTC Liquid formulations

7 VIPS Phase II Executive Summary Heat Stable CTC Liquid formulations pdf

1
VIPS Phase II executive summary:
Heat stable/Controlled temperature
chain (CTC) qualified liquid formulations
March 2020
2
About heat -stable/CTC qualified liquid formulations
? This innovation refers to…

7 VIPS Phase II Technical Note Liquid Heat Stable CTC Formulations pdf



VIPS PHASE 2 TECHNICAL NOTE

Heat stable/CTC qualified liquid formulations




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Microarray Patches

8 VIPS Phase II Executive Summary Microarray Patches pdf

1
VIPS Phase II executive summary:
Microarray patches (MAPs)
March 2020
2
Microarray patches (MAPs)
About MAPs
? MAPs consists of an array of micro -projections on a patch . The micro -projections are…

8 VIPS Phase II Technical Note Microarray Patches pdf

 


VIPS PHASE 2 TECHNICAL NOTE

Microarray patches




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Solid Dose Implants

9 VIPS Phase II Executive Summary Solid Dose Implants pdf

1
VIPS Phase II executive summary:
Solid - dose implants (SDIs)
March 2020
2
Solid -dose implants (SDIs)
About SDIs
? SDIs consist of vaccines (including antigens, adjuvants and excipients) that have been…

9 VIPS Phase II Technical Note Solid Dose Implants pdf

 


VIPS PHASE 2 TECHNICAL NOTE

Solid -dose implants




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